96-Well NanoSurface Plate

96-Well NanoSurface Plate

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96-well Plate Product Specifications

The 96-Well NanoSurface Plate features a glass bottom with nanopatterned surface topography, which provides a cellular microenvironment that mimics the aligned architecture of the native extracellular matrix.

  • Product Code: ANFS-0096

  • Coverslip Thickness: 0.175 +/- 0.015 mm

  • Glass Diameter: 20 mm

  • Approximate Pattern Growth Area: 0.33 cm²

  • Total Well Volume: 360 μL

  • Working Volume: 200 μL

  • Cell Culture Treated

  • ANSI/SLAS Microplate Size Compliant

  • Sterilized with Gamma Irradiation

  • Weight: 0.05 kg

  • Dimensions: 31 x 23 x 6 cm

  • Packaging Type:

    • 1 Plate – $225.00

    • 10 Plates – $1,620.00

Note: All numbers approximate and subject to revision.

Recapitulate the Extracellular Matrix in a Dish with NanoSurface Biomimetic Technology

NanoSurface Cultureware provides your cells and tissues a biomimetic surface to improve the physiological relevance of your experiments. Shortly after plating, cells cultured on NanoSurface Cultureware exhibit enhanced structural and phenotypic development when compared to cells grown on conventional dishes. NanoSurface topography promotes cytoskeletal reorganization and cellular alignment by mimicking the structure of the extracellular matrix. NanoSurface Cultureware is available in familiar standard formats, featuring glass-bottom wells for high-quality imaging.

  CDI iCell cardiomyocytes on a NanoSurface dish.

CDI iCell cardiomyocytes on a NanoSurface dish.

NanoSurface dishes promote the structural and phenotypic development of many cell types:

  • Fibroblasts

  • Cancer cells

  • Induced pluripotent stem cells

  • Mesenchymal stem cells

  • Human embryonic stem cells

  • And many more

  • Skeletal muscle cells

  • Smooth muscle cells

  • Neuronal cells

  • Cardiomyocytes

  • Endothelial cells

  • Epithelial cells

  • And many more


NanoSurface Cultureware vs. Conventional Dish

NanoSurface Cultureware dishes have a nanopatterned culture surface. This promotes cell alignment, where cells grown and elongate in the direction of the nanopattern. For example, primary- and stem cell-derived cardiomyocytes show aligned myofibrils across the monolayer surface and exhibit uniform anisotropic contraction patterns with enhanced contractile force and conduction velocity. The nanopatterned surface provides a cellular microenvironment that mimics the aligned architecture of the native extracellular matrix – improving physiological relevance by promoting cellular structural and functional development-- while still being compatible with most transmitted and fluorescent light microscopy techniques, including inverted optical microscope immersion objectives.

Conventional dishes do not utilize biomimetic surface topography, which results in random orientation of cardiomyocytes, disorganized contraction patterns, and immature functional phenotypes on the culture surface. The inaccuracies exhibited not only lead to imprecise test results, but can result in added workload and cost...maybe we can say more here about why conventional dishes aren’t the best method to use.

Comparison: Two-channel Confocal Image of CDI Cortical Neurons

dopaneuron-patterned.jpg

NanoSurface Cultureware

On NanoSurface Cultureware, neurofilaments (red) align along the direction of the nanotopography while dendrites (MAP2 stain; green) do not.

dopaneuron-flat.jpg

Conventional Cultureware

On conventional cultureware, the orientation of neurofilaments (red) is random and less representative of in vivo models.


NanoSurface Cultureware Benefits