NanoSurface Coverglasses (50-pack)

NanoSurface Coverglasses (50-pack)

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Product Specifications

Note: All numbers are approximate and subject to revision.
Product Code ANSF-CS25 ANSF-CS12 FLAT-CS25 FLAT-CS12
Surface Topography NanoSurface NanoSurface Unpatterned "Flat" Unpatterned "Flat"
Diameter 25 mm 12 mm 25 mm 12 mm
Coverglass Thickness No. 1.5 (0.175 +/- 0.015 mm) No. 1.5 (0.175 +/- 0.015 mm)
Approx. Pattern Growth Area 4.90 cm2 4.90 cm2
Weight 0.3 kg 0.3 kg
Dimensions 8 x 3 x 3 cm 8 x 3 x 3 cm
Packaging Volume 50 Cover Slips 50 Cover Slips 50 Cover Slips 50 Cover Slips

Recapitulate the Extracellular Matrix on a Coverglass with NanoSurface Biomimetic Technology

NanoSurface Cultureware provides your cells and tissues a biomimetic surface to improve the physiological relevance of your experiments. Shortly after plating, cells cultured on NanoSurface Cultureware exhibit enhanced structural and phenotypic development when compared to cells grown on conventional dishes. NanoSurface topography promotes cytoskeletal reorganization, cellular alignment, and functional development. NanoSurface Cultureware is available in familiar standard formats, featuring No. 1.5 glass-bottom wells for high-quality imaging.

NanoSurface dishes promote the structural and phenotypic development of many cell types:

• Cardiomyocytes • Endothelial cells
• Fibroblasts • Cancer cells
• Induced pluripotent stem cells • Mesenchymal stem cells
• Epithelial cells • And many more
• Human embryonic stem cells • Skeletal muscle cells
• Smooth muscle cells • Neuronal cells
 Human iPSC-Derived Cardiomyocytes (CDI iCell) NanoSurface Coverglass.

Human iPSC-Derived Cardiomyocytes (CDI iCell) NanoSurface Coverglass.


NanoSurface Cultureware vs. Conventional Unpatterned “Flat” Cultureware

NanoSurface Cultureware features a nanopatterned culture surface which provides a cellular microenvironment that mimics the aligned architecture of the native extracellular matrix – improving physiological relevance by promoting development. Cells can align, elongate, grow, and even migrate along the pattern while exhibiting more physiologically representative structural and functional phenotypes.

Conventional cultureware does not utilize biomimetic surface topography, which results in random structural orientation. The disorganized isotropic cell and tissue architectures result in immature functional phenotypes that do not reproduce in vivo function. These inaccuracies lead to imprecise, hard-to-reproduce results and wasted time and effort.

Comparison: Two-channel Confocal Image of CDI Cortical Neurons

dopaneuron-flat.jpg

Conventional Cultureware

On conventional cultureware, the orientation of neurofilaments (red) is random and less representative of in vivo models.

dopaneuron-patterned.jpg

NanoSurface Cultureware

On NanoSurface Cultureware, neurofilaments (red) align along the direction of the nanotopography while dendrites (MAP2 stain; green) do not.


NanoSurface Cultureware Benefits

High-quality Imaging

Compatible with high-magnification, high-NA transmitted light and fluorescence microscopy techniques. No spectral loss across commonly used fluorophores.

Reproducibly Structured Cell Cultures

Highly uniform, precise, and accurate nanopatterns ensure that your results are consistent from plate to plate.

Industry Standard Culture Formats

Cultureware comes in a variety of ANSI/SLAS compliant form factors to guarantee compatibility with existing instrumentation and hardware.

Biomimetic Technology

Nanoscale topography mimics the aligned architecture of the extracellular matrix.