Skeletal Muscle Models
Curi Bio's 3D Engineered Muscle Tissues (EMTs) enable in vitro models of skeletal muscle contractility and Curi Bio’s 2D skeletal muscle model utilizes microtissues built by structurally maturing human skeletal muscle cells.
Cardiac Models
Curi Bio’s 3D Engineered Heart Tissues (EHTs) enable in vitro models of cardiac muscle contractility while our 2D heart model utilizes microtissues built by structurally maturing human iPSC-derived cardiomyocytes.
Disease Models
Curi Bio has licensed and/or developed advanced human tissue models for a number of monogenic disorders, including Duchenne Muscular Dystrophy (DMD) (see our DMD case study). Additional models include:
Myotonic Dystrophy Type 1 (DM1)
Facioscapulohumeral Muscular Dystrophy (FSHD)
X-linked Myotubular Myopathy (XLMTM)
Hypertrophic & Dilated Cardiomyopathies (HCM/DCM)
and More
Contact our team to discover how Curi Bio can help accelerate your disease research and therapeutic discoveries by providing access to our pre-made disease model library, tissue models, and tissue-specific biosystems. Curi Bio is actively pursuing additional partnerships to create new disease models.
Histological analysis of 3D EMT cross sections shows distribution of myosin positive myotubes in control (WT) but not DMD tissues.