All-in-One Cell Stretching Instruments

The Cytostretcher family of instruments is a powerful and easy-to-use integrated solution for cell mechanics research. The Cytostretcher and Cytostretcher-LV empower you to gain new insights into the relationship between the cell and its microenvironment – important for nearly all mammalian cell types. NanoSurface’s patterning technology provides structural cues that recapitulate the native ECM within flexible stretching chambers. The included NaOMI software provides total experimental control in a clean, intuitive interface. 

  • The Cytostretcher can be used to stretch cells on the bench-top or in a cell culture incubator.

  • The Cytostretcher-LV can be used to perform stretching experiments on an optical microscope.

The flexibility and power of the Cytostretcher family of instruments ensures that every cell stretching experiment can be implemented with ease and precision. 


NanoSurface Cytostretcher

Flexible Software Allows for Unprecedented Experimental Control 

NaOMI – the NanoSurface Operational Mechanics Interface allows for intuitive control of stretching routines and protocols for NanoSurface Cytostretcher instruments. Learn more about NaOMI below.

Compact Design 

The Cytostretcher is extremely compact, easily integrating into your existing cell culture workflow. It can be operated on the bench-top or alongside other cultures inside a standard cell culture incubator – saving valuable space. 

  • Instrument footprint: 280 x 102 x 65 mm

  • Control Unit footprint: 110 x 64 x 60 mm 

Run Multiple Experiments in Parallel 

Flexible Cytostretcher Chambers are available in a variety of formats, so you can mechanically condition many cultures in parallel. Larger chambers offer more culture area (up to 25 cm2). Smaller chambers offer higher throughput (up to 24 wells). 

  • 6 Chambers x 1 well, each well 5 mm x 5 mm

  • 6 Chambers x 2 wells, each well 5 mm x 5 mm

  • 3 Chambers x 1 well, each well 12 mm x 12 mm

  • 1 Chamber x 1 well, each well 50 mm x 50 mm

  • 1 Chamber x 24 wells, each well 6 mm x 6 mm 

Convenient Control Unit 

The Cytostretcher Control Unit is a small, lightweight module that can be magnetically attached to the exterior of a cell culture incubator. 


NanoSurface Cytostretcher-LV

Cytostretcher-LV_Full-setup-with-ECU-spotlights.jpg

Observe Cells While Stretching 

Image live cells during your stretch routines. The Cytostretcher-LV and Cytostretcher Chambers are compatible with transmitted light and high-NA fluorescence microscopy, including immersion objectives. 

Maintain Focus While Stretching 

The Cytostretcher-LV is the only cell mechanical stimulation system that enables consistent sample focus during stretch. 

Universal Mounting Frame K 

Allows for broad compatibility with many industry standard microscopes and stages. Other mount options are available upon request. 

Up To 6 Parallel Cultures 

Configure with up to six 25 mm2 wells or one 144 mm2 chamber. 

  • 3 Chambers x 1 well, each well 5 mm x 5 mm

  • 3 Chambers x 2 wells, each well 5 mm x 5 mm

  • 1 Chamber x 1 well, each well 12 mm x 12 mm

Flexible Software Allows for Unprecedented Experimental Control 

NaOMI – the NanoSurface Operational Mechanics Interface allows for intuitive control of stretching routines and protocols for NanoSurface Cytostretcher instruments. Learn more about NaOMI below.

Environmental Control Unit (ECU) for Long-Term Imaging

The Environmental Control Unit (ECU) is a microscope stage-top incubator that provides complete control of biological culture conditions, including temperature, humidity, and CO2 concentration. An included thermal camera allows for quick and continuous monitoring of sample temperature. 

ECU Touch Screen Panel 

A touch-panel interface provides easy control of culture conditions. 


Nanopatterned or Flat Cytostretcher Chambers

 Traditional “Unpatterned” Flat Surface

Traditional “Unpatterned” Flat Surface

 SEM Micrograph of NanoSurface Topography

SEM Micrograph of NanoSurface Topography

Cytostretcher Chambers are available with either NanoSurface topography that mimics the aligned architecture of the native extracellular niche or with traditional unpatterned “flat” surfaces. Patterned chambers feature topography either aligned in parallel or perpendicular to the direction of applied stretch. NanoSurface topography promotes the development of physiologically-relevant structures and phenotypes in many cell types: 

• Cardiomyocytes • Endothelial cells
• Fibroblasts • Cancer cells
• Induced pluripotent stem cells • Mesenchymal stem cells
• Epithelial cells • And many more
• Human embryonic stem cells • Skeletal muscle cells
• Smooth muscle cells • Neuronal cells

Cytostretcher Chamber Formats

NanoSurface Cytostrecher

  • 6 Chambers x 1 well, each well 5 mm x 5 mm

  • 6 Chambers x 2 wells, each well 5 mm x 5 mm

  • 3 Chambers x 1 well, each well 12 mm x 12 mm

  • 1 Chamber x 1 well, each well 50 mm x 50 mm

  • 1 Chamber x 24 wells, each well 6 mm x 6 mm 

NanoSurface Cytostretcher-LV

  • 3 Chambers x 1 well, each well 5 mm x 5 mm

  • 3 Chambers x 2 wells, each well 5 mm x 5 mm

  • 1 Chamber x 1 well, each well 12 mm x 12 mm 


Cytomechanics, Unlocked

NaOMI Software Icon

NaOMI – the NanoSurface Operational Mechanics Interface allows for intuitive control of stretching routines and protocols for NanoSurface Cytostretcher instruments. 

  • Intuitive user interface with powerful editing tools 

  • Build simple stretch protocols, or complex multi-step stretch routines – no programming skills required 

  • Save protocols for repeated use or later modification 

  • Control stretch velocity, duration, frequency, magnitude, delay times before and after stretch, and the type of waveform used to drive the stretch protocol 

  • Computer-free operation after protocol setup 

  • Protocol graph for easy visualization 

  • Standard USB connectivity, compatible with Windows 10